Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
Abcam Rabbit Anti-Human IgM mu chain (Biotin).
Rabbit Anti-Human IgM mu chain (Biotin).
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 647 Rabbit anti-Human IgG Fc
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to be involved in several processes including activation of immune response defense response to other organism and phagocytosis Predicted to act upstream of or within several processes including immunoglobulin mediated immune response positive regulation of hypersensitivity and positive regulation of phagocytosis Located in extracellular space
ABclonal Technology APC Rabbit anti-Human CD30 mAb
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is expressed by activated but not by resting T and B cells TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human CD314
Natural killer (NK) cells are lymphocytes capable of lysing tumor and virus-infected cells without prior activation as well as regulating immunity NK cells express several calcium-dependent (C-type) lectins which influence their function The NKG2 gene family located in the NK complex includes genes expressed in NK cells This gene encodes a transmembrane protein with a C-type lectin domain binding ligands like MHC class I chain-related A and B proteins and UL-16 binding proteins Ligand-receptor interactions activate NK and T cells aiding immune system recognition of stressed cells This protein and its ligands are potential therapeutic targets for immune diseases and cancers Read-through transcription occurs between this gene and the upstream KLRC4 family member in the same cluster
ABclonal Technology 488 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 488 Rabbit anti-Human CDCP1
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis Alternative splicing results in multiple transcript variants of this gene
ABclonal Technology 647 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
Jackson Immuno Research Labs Alkaline Phosphatase-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
Alkaline Phosphatase-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
Jackson Immuno Research Labs Alexa Fluor 594-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgG Fcγ Fragment Specific
Alexa Fluor 594-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgG Fcγ Fragment Specific
ABclonal Technology PE Rabbit anti-Human CD48 mAb
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD11a
ITGAL encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) which is expressed on all leukocytes LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1-3 (intercellular adhesion molecules 1 through 3) and also functions in lymphocyte costimulatory signaling Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-/Human CD55
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis This gene is located adjacent to a closely related gene on chromosome 1
ABclonal Technology 488 Rabbit anti-Human ROR1
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia Alternative splicing results in multiple transcript variants encoding different isoforms